Multimodal approach for acute pain

Consider a multimodal approach:
the standard of care

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Acute pain can be characterized as a sudden, sharp pain lasting less than 4 weeks.1

Multimodal therapy is recommended for acute pain and is achieved using2,3:

  • Open combinations (ie, concomitant administration) of individual agents
  • Fixed-dose combinations (FDCs)
  • Multimodal agents (ie, single agents with multiple mechanisms of action)
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This allows patients to2:

  • Maximize their pain relief while minimizing their exposure to opioids
  • Receive reduced doses, which may reduce the risk of adverse events of the components for each drug
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Medications for the management of acute pain fall into 2 categories:
nonopioid analgesics and opioid analgesics.3

Nonopioid therapies are preferred for many common types of acute pain.
Clinicians should consider opioid therapy for acute pain only if3:

Use the lowest effective dose for the shortest duration of time per individual treatment plan.

A unique co-crystal works to help manage acute pain in appropriate patients1

Get important


  1. Dowell, D. Draft Updated CDC Guideline for Prescribing Opioids: Background, Overview, and Progress. Published July 16, 2021. Accessed January 25, 2022.
  2. Almansa C, Frampton CS, Vela JM, Whitelock S, Plata-Salamán CR. Co-crystals as a new approach to multimodal analgesia and the treatment of pain. J Pain Res. 2019; 12:2679-2689. doi:10.2147/jpr.s208082.
  3. US Dept of Health and Human Services. Pain management best practices. Published May 9, 2019. Accessed November 24, 2021.