Morphine milligram equivalents (MMEs)

For appropriate patients with acute pain, SEGLENTIS provides a treatment option with a lower daily MME than commonly prescribed opioid analgesics*1-6

The daily dose of SEGLENTIS is below the CDC threshold for relatively low opioid dosage1,3,5

MMEs provided by some commonly prescribed opioid analgesics1-6

CDC, Centers for Disease Control and Prevention.

MME is an opioid dosage's equivalency to that of morphine. The MME-per-day metric is often used as a gauge of the overdose potential of the amount of opioid that is being given at a particular time.5

Dosage thresholds are based on overdose risk when opioids are prescribed for pain. Higher dosages of opioids are associated with higher risk of overdose and death—even relatively low dosages (20-50 MMEs per day) increase risk.

MME value based on the maximum daily dose of 60 mg of oxycodone hydrochloride/acetaminophen and hydrocodone bitartrate/acetaminophen, 400 mg of tramadol hydrochloride, and 176 mg of tramadol hydrochloride from SEGLENTIS.

The Phase 3 factorial study compared efficacy and safety at lower doses of tramadol hydrochloride and celecoxib than are optimal for the treatment of acute pain. The dosages studied for the individual components were not the maximum daily dosages.

Please read Important Safety Information continued throughout and full Prescribing Information.

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  1. SEGLENTIS [prescribing information]. Montgomery, AL: Kowa Pharmaceuticals America, Inc.; October 2021.
  2. Ultram (tramadol hydrochloride) tablets [prescribing information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; September 2021.
  3. Opioid oral morphine milligram equivalent (MME) conversion. Utah Department of Health Medicaid. Accessed March 25, 2022.
  4. Oxycodone hydrochloride and acetaminophen tablet [prescribing information]. Paramus, NJ: Mayne Pharma Inc.; May 2021.
  5. Centers for Disease Control and Prevention. Calculating total daily dose of opioids for safer dosage. Accessed March 18, 2022.
  6. Hydrocodone bitartrate and acetaminophen tablets [prescribing information]. Newtown, PA: KVK-Tech, Inc.; August 2020.