Morphine milligram equivalents (MMEs)

For appropriate patients with acute pain, SEGLENTIS tablets provide a treatment option with a lower MME*, at maximum daily dosages, than some commonly prescribed opioid analgesics1-3,5,6

  • SEGLENTIS is equivalent to less than half the MMEs (35.2 vs 80) of the maximum daily dose of tramadol hydrochloride alone in acute pain.1-3,7
  • SEGLENTIS contains a Schedule IV opioid, which is defined as having a low potential for abuse and low risk of dependence compared with Schedule II or III opioids.4

CDC, Centers for Disease Control and Prevention; MME, morphine milligram equivalent.

Morphine milligram equivalents (MMEs) is an opioid dosage's equivalency to morphine. The MME per day metric is often used as a gauge of the overdose potential of the amount of opioid that is being given at a particular time.4

MME value based on the maximum daily dose of 60 mg of oxycodone hydrochloride/acetaminophen and hydrocodone bitartrate/acetaminophen, and 176 mg of tramadol hydrochloride from SEGLENTIS.1,2,5,6

Please read Important Safety Information continued throughout and full Prescribing Information.

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  1. Seglentis (celecoxib and tramadol hydrochloride) tablets, for oral use, C-IV [prescribing information]. Kowa Pharmaceuticals America, Inc. October 2021.
  2. Viscusi ER, de Leon-Casasola O, Cebrecos J, et al. Celecoxibtramadol co-crystal in patients with moderate-to-severe pain following bunionectomy with osteotomy: a phase 3, randomized, double-blind, factorial, active- and placebo-controlled trial. Pain Pract. 2023;23(1):8-22. doi: 10.1111/papr.13136. Epub 2022 Jul 8. PMID: 35686380
  3. Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022. MMWR Recomm Rep. 2022;71(3):1-95. doi: 10.15585/mmwr.rr7103a1
  4. United States Drug Enforcement Agency. Drug scheduling. Accessed January 29, 2023.
  5. Hydrocodone bitartrate and acetaminophen tablets, USP 5 mg/300 mg, 7.5 mg/300 mg, 10 mg/300 mg, 5 mg/325 mg, 7.5 mg/325 mg and 10 mg/325 mg [prescribing information]. KVK-Tech, Inc. August 2020. Accessed January 29, 2023.
  6. Oxycodone and acetaminophen tablets, USP CII [prescribing information]. Mayne Pharma, Inc. April 2021. Accessed January 29, 2023.
  7. Ultram (tramadol hydrochloride) tablets, for oral use, C-IV [prescribing information]. Janssen Pharmaceuticals, Inc. September 2021.